Safety of antifibrinolytic therapy during cardiac surgery and randomized controlled trials.

نویسندگان

  • A Koster
  • A Zittermann
  • U Schirmer
چکیده

1 Koster A, Bergermann J, Zittermann A, et al. Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. Br J Anaesth 2013; 110: 34–40 2 McMullan V, Alston RP. Aprotinin and cardiac surgery: a sorry tale of evidence misused. Br J Anaesth 2013; 110: 675–8 3 Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion (review). Cochrane Database Syst Rev 2011. Available from http:// onlinelibrary.wiley.com/doi/10.1002/14651858.CD001886.pub4/ abstract (accessed 29 Jan 2013) 4 Fergusson DA, Hebert PC, Mazer CD, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Eng J Med 2008; 358: 2319–31

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منابع مشابه

Safety of antifibrinolytic therapy during cardiac surgery and randomized controlled trials

1 Koster A, Bergermann J, Zittermann A, et al. Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. Br J Anaesth 2013; 110: 34–40 2 McMullan V, Alston RP. Aprotinin and cardiac surgery: a sorry tale of evidence misused. Br J Anaesth 2013; 110: 675–8 3 Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolyti...

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While conventional practice is to discontinue aspirin prior to elective cardiac surgery there is evidence that its continuation may be associated with improved perioperative outcomes. However, uncertainty exists regarding the efficacy of antifibrinolytic agents in the presence of aspirin. We performed a systematic review and meta-analysis of the literature to address the question of the effects...

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Impact of aprotinin and renal function on mortality: a retrospective single center analysis

BACKGROUND An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing bleeding. Aprotinin was removed from the market by the U.S. Food and Drug Administration after a large prospective, randomized clinical trial ...

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Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis

BACKGROUND Routine use of antifibrinolytic agents in spine surgery is still an issue of debate. OBJECTIVE To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA, traditionally known as Amicar) in reducing perioperative blood loss and transfusion requirements in scoliosis surgery. MET...

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Antifibrinolytic drugs and perioperative hemostasis.

Although excessive bleeding is widely recognized as a common complication of cardiac surgery, the recent success of antifibrinolytic drugs as prophylactic hemostatic agents has received little attention outside the surgical literature. The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of antifibrinolytic drugs as hemostatic agents suggest...

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عنوان ژورنال:
  • British journal of anaesthesia

دوره 110 6  شماره 

صفحات  -

تاریخ انتشار 2013